KEY TO BLOOD BARRIER OPEN WAY FOR ALZHEIMER’S AND STROKE

According to Dr. Christer Betsholtz who has led the study of Blood-Brain barrier detect that Blood-Brain barrier(BBB), guarded the brain from any dangerous chemicals that might naturally form in the blood and at the same time this blood-brain barrier also block any drugs going into the brain.
The solution to the Blood-brain barrier (BBB) was detected by a group of scientist at the
Swedish Medical University Karolinka Institute. “The new founding state that a potential answer to this problem”
The key to the BBB is located in the “blood vessel walls” which is knows as pericytes, and the scientist thought the new founding to (BBB) will add to the treatment of stroke and Alzheimer.
Inside the brain the pathway in which the capillary walls allowed certain particles carried by “the blood, such as the plasma proteins albumin and immunoglobulin, out into the surrounding tissue is closed off.
The groups discover recently the “capillary permeability” inside the brain had been said to be number one factor coursing “neurodegenerative diseases, such as Alzheimer and Parkinson.
Inside the article, Professor Betsholtz explain further that “Our knowledge of how the BBB is regulated could be used in two ways,”-
1. To protect the brain under conditions such as stroke and inflammation that lead to the opening of the BBBB and the release of neurodamaging substances;
2. and to open the barrier temporarily to allow the transport of drugs against neurodegenerative and other diseased of the brain.
The group also discover Unknown molecular mechanism” which means if the molecule is absent, a process called transcytosis gives way though the “capillary wall” in other for the molecules of various sizes, plus large plasma proteins can go from the blood to the brain.
They also found that the pericytes control another brain cell known as astrocytes. Astrocyte work with BBB through a system called end-feet which envelop the capillaries and control water and ion flow.
Finally, they discover a cancer drug “Imatinib” that inhibits a particular protein for cell growth has the same effect in the presence of pericyctes and also shut the capillary wall transport part.

WWW. CancerCenter.com

Summary of the Article


According to Dr. Christer Betsholtz who has led the study of “Blood-Brain Barrier” detect that “Blood-Brain barrier”(BBB), guarded the brain from any dangerous chemicals that might naturally form in the blood and at the same time this “Blood-Brain Barrier” also block any drugs going into the brain.
The solution to the “Blood-brain barrier” (BBB) was detected by a group of scientist at the Swedish Medical University Karolinka Institute. “The new founding state a potential answer to this problem”

The new finding about “Blood-Brain Barrier” is that the barrier is protected by pericycles which restrict the passage of solutes. According to Professor Betsholtz his results show us that the barrier can be open in a system that allow the passage of molecules of different sizes at the same time keeping the basic functions of the brain operating properly.
In other part of the body the capillary wall such as plasma proteins “albumin and immunoglobulin” allow certain substances carried by the blood, out into the surrounding tissue. In the brain, things are different, the pathway is closed.

"Our new knowledge of how the BBB is regulated could be used in two ways," says Professor Betsholtz. "To protect the brain under conditions such as stroke and inflammation that lead to the opening of the BBB and the release of “neurodamaging” substances; and to open the barrier temporarily to allow the transport of drugs against neurodegenerative and other diseases of the brain."

Comment
My God bless Professor Betsholtz and the group of scientist at the Swedish Medical University Karolinka Institute for this new founding of how the Blood-Brain Barrier can be open to control disease of Alzheimer and stroke or any brain disease (Alzheimer is a type of demesia that affect old people from age seventy to hundred ). By opening the Blood brain barrier that prevent drug or solute going into brain will allow medicine to be use to cure stroke and Alzheimer disease.



By Justina Olatunbosun